Luiz has not featured since last month's 4-0 away win over Qarabag in the Champions League, and the mystery over his injury has fuelled speculation that tension with Conte is the real reason for his absence and that the situation is threatening to bring an end to his second spell at Stamford Bridge.
Blues boss Conte said on Friday that the Brazilian is still struggling with a knee problem and continues to be assessed by the club's medical staff.
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Since arriving back at Chelsea, Luiz has certainly bolstered his reputation, and was brilliant in their title winning season last term, but a falling out with Antonio Conte and of course the form of Andreas Christensen has made it very hard for him to get back into the side, and he's made Conte very aware of his feelings as the duo looked to get their working relationship back on track.
"This is a serious problem but we hope to solve this problem soon". "He trained with us two days ago, and also today".
No wonder, with the Citizens maintaining their impressive scoring rate that has seen them net at least twice in their last 10 matches and 52 in all - an average of more than three a game across their 17 fixtures. "To have these 15 wins in a row, also you must be lucky, because in many games they won at the last minute or five minutes to go".
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Southampton manager Mauricio Pellegrino wants a reaction from his side, and ahead of this game, he told the club's official website: "It's really important for us because this is our main job and we want to show we are well prepared and be consistent". "Southampton are a good team with a lot of good young players with a great future and will make us suffer".
So, that's not so much a title concession from Conte but him pointing out that it will be very tough for his team to claw any points back on City.
"The players are very fast".
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"Ancelotti is famed for being diplomatic, for listening to his players and how they want to play". [Shane] Long, [Sofiane] Boufal. I have this sensation. We must pay great attention.