"Nobody believes we will go through".
Guardiola also eased the pressure by reiterating City have time on our side in the bid to secure the title.
His statement lacked conviction.
Having watched their rivals Manchester United dominate English football for the majority of the 1990's and the new millennium, City fans are relishing their opportunity to get one over their bitter foes on Saturday at the Etihad Stadium.
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Guardiola altered his normal formation and left Raheem Sterling on the bench, with midfielder Ilkay Guendogan brought into the starting line-up.
He said: "We lost 3-0".
European success is in Liverpool's DNA and their supporters feel it. The key attacking options - Gabriel Jesus and Sergio Aguero - were both left on the bench. Manchester City failed to cope with Liverpool's intense pressing and capitalized on any mistake that the league leaders made - with the first goal coming from a mistake by Leroy Sane where he mishit a long diagonal ball and another mistake by Kyle Walker who failed to clear the ball away from danger, allowing Muhammad Salah to continue his terrific season with a goal.
Pep Guardiola insists he has not changed his selection plans for Saturday's Manchester derby in the wake of City's 3-0 defeat at Liverpool in midweek, Soccerway reports.
A semifinal loss with Barcelona in 2012 was followed by three straight exits at the last four with Bayern.
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As City boss, Guardiola has only managed to beat Klopp only once.
Pep Guardiola's men will become the first team in the league's 26-year history to wrap up the title with six games to spare if they beat United at the Etihad - a fitting end to a season of nearly total dominance in the league. What followed was a kind of fudged change, bolstering his central midfield but leaving another area of the field undermanned.
Man City would need to put the attack behind him when they host the Reds for the second leg of the Champions League next Tuesday. "You know how it goes between City and United, you know the history, so it would be historic".
But despite showing a big frustration with Manchester City's performance against Liverpool, he claims that they should now think of the weekend's game against Manchester United, which could give them the league title.
Two police officers were hurt during the chaotic scenes yesterday evening - one struck by an object and another was cut by glass cut, according to Match Commander Superintendent Paul White.
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Mourinho had a simple warning to his United players in the dressing room at halftime.