"We have learned ways to overcome our enemies, and we can harm the enemies vital interests anywhere we want", Salami added.
Since Syria was gripped by civil war in March 2011, Iran has remained a close ally of the country and supported its legitimate government in the face of foreign-backed militancy at the request of Damascus.
Tensions between Israel and Iran have been steadily escalating since an Iranian drone that breached Israeli airspace on February 10 was shot down by the Israeli Air Force.
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The minister stressed that Israel is ready for every scenario, including a multi-front scenario, adding: "I don't remember a time when we were so prepared and so ready, both the army and the people of Israel".
"We hear the threats from Iran".
Zarif went on to accuse Israel of escalating tensions in Syria by "routinely" violating its territory, referring to two recent alleged Israeli strikes on a regime military target used by the Revolutionary Guards to launch an explosives-laden drone inside Israeli territory earlier this year.
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New York Times journalist Todd Friedman published a statement that he considered a "slip of the tongue" from a senior Israeli army officer in which he said Israel had hit Iran's base and killed Iranian officers. Israeli officials have repeatedly stated that Israel will not allow Iran to entrench itself in Syria, marking it as a "red line" that it will fight for militarily if necessary.
The images obtained by Israel's Channel 10 depicted the base before and after the airstrike, revealing "surgical precision" and the attack's limited scope.
Israel, said Salami, was living "in the dragon's mouth". "(Referring to the July war in Lebanon in 2006) you will have no way to runaway except the sea", Salami is quoted as saying. He called for those who are on the Northern borders to think carefully about what they are doing, indicating Iran and the Lebanese Hezbollah militia.
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Then in February, thousands of U.S. troops came to Israel for five days of drilling together with the IDF and IAF in the biennial Juniper Cobra exercise, which involved a simulation of a two-front, massive missile attack on the Jewish state.