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US President Donald Trump pulled out last month from the 2015 accord between Iran and world powers that lifted sanctions on Tehran in exchange for curbs to its nuclear program.
Signed in 2015, the pact was created to prevent Iran from obtaining a nuclear bomb in return for the removal of global sanctions that had impaired its economy.
Shortly after Khamenei's speech, French automaker PSA announced it was pulling out of two joint ventures to sell its cars in Iran owing to the USA sanctions.
Before the deal was reached, Tehran enriched uranium to up to 20% purity.
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Earlier on Tuesday, Iran's atomic energy chief Ali Akbar Salehi emphasized that Tehran had developed infrastructure to produce electricity at the country's Natanz facility, saying that the Islamic Republic had notified the United Nations that it will install centrifuges for the uranium enrichment there.
The Europeans have proposed hammering out a supplementary deal with Tehran covering its ballistic missile programme as well as its interventions in countries such as Lebanon, Syria, Iraq and Yemen.
"Iran said there had only been feasibility and scientific studies but what we see is that Iran ran a fully fledged nuclear weapons program and that it followed directions from the political levels", the official added.
Israel has proposed that "a military coalition" be formed against Iran in case Tehran pursues "military-grade" uranium enrichment, suggesting that the military force would comprise of the Israeli regime, the USA, the Western states and their Arab allies.
German Chancellor Angela Merkel, right, and Israeli Prime Minister Benjamin Netanyahu, left, address the media during a joint press conference as part of a meeting at the Chancellery in Berlin.
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Earlier this week, Iranian Ayatollah Khamenei again issued the regime's long held threat to annihilate Israel from the map. Iran will announce that the process of increasing the capacity to produce... He said France will continue to work with the existing deal which it considers the best way to control the country's nuclear activity.
Last week, the chief executive of French oil giant Total - a symbol of foreign companies' return to Iran after 2015 - said the chances of winning sanctions exemptions were "very slim".
As EU businesses face retaliation from the United States for doing business with Iran, many are opting to avoid Iran.
The two leaders also discussed the Israelo-palestinian conflict with Macron once again condemning Donald Trump's decision to move the U.S. embassy to Jerusalem and the deaths of at least 58 Palestinians in mid-May.
French president Emmanuel Macron and Israeli Prime Minister Benyamin Netanyahu met in Paris on Tuesday for talks largely focusing on Iran.
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