And Ronaldo was the man who helped him off the pitch.
The other last-16 match pits a talented Croatia team led by Luka Modric that had a flawless record in the group phase against Denmark, but they will have to go some to emulate the drama of Saturday's first two last-16 matches.
World Cup 2018Messi's World Cup got off to the worst possible start when he missed a penalty in Argentina's opening game, which ended in a disappointing 1-1 draw with tournament debutants Iceland.
Edinson Cavani outshines Ronaldo but injury could dampen Uruguay's long-term hopes
Edinson Cavani passes it across the field to Luis Suarez who crosses right back to Cavani for the header in the top right. With the "Fubo Premier" bundle, you will get access to all four of the World Cup soccer TV channels in most markets.
Unless you are Argentinian or Portuguese, there's no need to shed a tear for them because the spotlight will now deservedly be on the new wave of global superstars - 19-year-old Frenchman Kylian Mbappe sizzled with his pace and brace in the 4-3 win over Argentina, 22-year-old Mexican Hirving Lozano tore Germany apart, and 24-year-old Englishman Harry Kane is living up to his billing as the world's best No. 9 with five goals so far in this tournament.
The Paris Saint-Germain striker opened the scoring with an early header and curled a superb first-time shot past Rui Patricio to win the match after a Pepe equaliser.
With La Celeste set to face Seleccao das Quinas on Saturday night in a much-anticipated Round of 16 clash at the Fisht Olympic Stadium in Sochi, Suarez takes the view that club rivalries play no part on such a big occasion.
"We're now speculating, was this the last time we saw Ronaldo and Messi at the World Cup?".
The Real Madrid forward could not add to his four goals in the first two matches, failing to improve his record of failing to score in all six World Cup knockout matches he has played.
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Spain's top scorer, forward Diego Costa (L), warms up with teammates during a training session at the Luzhniki Stadium in Moscow, on June 30, on the eve of their Russian Federation 2018 World Cup round of 16 match against Russian Federation. We wanted to win, we fought well, but Uruguay should be congratulated.
The French squad is packed with talented young players like N'golo Kante, Paul Pogba and Kylian Mbappe, while established stars like Antoine Griezmann remain a scoring threat. "It's always a strong team to play against".
"Statistics are made to be broken", Hierro said. "We'll see what happens, we'll do [medical] exams".
Denmark coach Age Hareide said his side's match against Croatia could boil down to who comes out on top in the midfield battle between Tottenham powerhouse Christian Eriksen and Modric.
But, saying Federation Internationale de Football Association was aware of incidents such as that during Argentina's vital group game against Nigeria in St Petersburg, he added: "We would expect all players, former players, staff, fans, everyone to behave in a respectful manner".
Deschamps and Lloris aware of Messi menace to France's World Cup dream
The Barcelona star is heating up, scoring his first goal of the 2018 World Cup against Nigeria in his squad's last match. He is the last Argentinean player to score against France , back in February 2009 in a friendly (2-0).
Hareide said his team would show far more thrust on Sunday. Portugal seemed like one of the teams that could have won the entire 2018 World Cup, but they're not going to watch the rest of the tournament from home. "That's why we need someone to provide us with information".