Images showed a burning aircraft marked "Martin's Air Charter".
The 1954-built plane was soon to be flown to the Aviodrome air museum, near the central Dutch city of Lelystad, via Egypt, Croatia and Austria. The plane crashed killing one person and injuring 20 others with injuries ranging from minor to critical, according to Russel Meiring, a spokesman for paramedic company ER24.
Eyewitnesses described seeing the plane attempt to veer toward Wonderboom airport, then hearing an explosion.
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"The plane had 19 passengers on board which includes the pilot and the engineer", Johan Pieterse, the local government emergency services spokesman, told AFP.
"We are unsure as yet of how the incident occurred".
The plane, which had been expected at the Aviodrome, 'crashed in South Africa during take-off on a test flight, ' it said.
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Aviodrome wrote on Facebook that it was "hugely shocked", by the crash.
A charter aircraft crashed in Kameeldrift on Tuesday afternoon.
The plane was likely on its way to Wonderboom airport in north Pretoria, the Tshwane Metro Police Department said.
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Civil Aviation Authority investigators were at the scene and started the process of determining the cause of the accident.