The bus was carrying 49 passengers and heading to Phoenix, Arizona.
Investigators from the National Transportation Safety Board were dispatched to the scene, along with the New Mexico State Police Crash Reconstruction Unit. "The officers did a great job of sifting through the rubble to get survivors out". "Officers and EMS are still working this scene actively".
Police say the westbound lane is closed as they investigate what caused the accident that caused multiple injuries and casualties.
It collided with the truck around 12:30 p.m. on Interstate 40 near the city of Thoreau, located about 100 miles west of Albuquerque, the state police said. Nearby was an overturned vehicle and what appeared to be a truck trailer on its side, with contents spilled on the median.
Preliminary information indicated the semi was headed east when it blew a tire, sending the rig across the median and into oncoming traffic where it smashed into the bus, New Mexico State Police said. Injuries to the driver of the semi-trailer truck were not life threatening, state police said. They also have not said how many people were killed or how many were injured.
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The company says it is cooperating with authorities and plans its own investigation. "Our thoughts and prayers are with everyone as we continue to give our support to all affected".
"It was terrible, there was people trying to climb out of the windows of the bus. bystanders trying to help people getting ladders out of their truck to get to windows of Greyhound bus to assist", a witness told KRQE. It's unclear where the three additional people died.
At least 33 people have been taken to area hospitals, some of whom were in critical condition, ABC News reported.
"It was intense", Mr Jones said.
One witness, Chris Jones, was driving along the highway when he came upon the crash site. Some families were among the patients, as well as four children, he said.
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As of Thursday night, seven deaths had been confirmed.
A large number of emergency services staff can be seen in attendance.
"These are the types of things we prepare for and hope we never have to deal with", Gaines said. The injured are being treated at Gallup Indian Medical Center. The rest are in stable condition.
The crash occurred near the town of Thoreau.
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