Meanwhile, Osaka advanced to the third round and had Madison Keys on the ropes before the American rallied for the win.
Former World No 1 Karolina Pliskova won her 11th WTA Tour title after she defeated US Open champion Naomi Osaka with 6-4, 6-4 in the finals of the Pan Pacific Open on Sunday. She opened her campaign by rallying from a set down to oust Australia's Daria Gavrilova 4-6 6-4 6-4 to reach the quarterfinals where she faced Alison Riske.
Wuhan Open organisers confirmed Osaka's withdrawal due to a viral illness on their Twitter page.
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"I have literally never been so exhausted in my entire life", she told reporters.
"To play the final of the U.S. Open and then to come here, I think I did pretty well", Osaka said.
Not since Victoria Azarenka in 2012 has a player won their first tournament after a maiden Grand Slam triumph, but Osaka has been playing some excellent tennis and will surely receive the vocal backing of her home crowd. "Stan is one of the best players in the world and I'm really proud of myself after I could beat him finally. So I just wanted to be patient and wait for my chances", Pliskova added after capturing her 11th career WTA title without offering up a single break point. "For a while it was looking like it maybe could be under two hours, but not really".
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Fittingly, Pliskova wrapped up the match in the same way Osaka had started it - with an ace - to take victory. "It's always a pleasure to play in the final". She finished with 26 unforced errors and admitted to being exhausted after the match.
Osaka could not recover after being broken by the world number eight in the fifth game of the first set and, as the strain began to show, she called for coach Sascha Bajin and groaned: "I feel so stressed out".
In the deciding set, Klizan broke in the third game. After making the last eight in Hiroshima the previous week to go with similar showings in San Jose, Mallorca and Monterrey - as well as the final in Rabat - the 25-year-old could be set for a big 2019.
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Osaka, supremely confident and in top form coming into the final off the back of 10 consecutive wins, looked anxious throughout the contest and allowed Pliskova to win easily in just over an hour.